A Common Pharmacophoric Footprint for AIDS Vaccine Design
Identifieur interne : 003098 ( Main/Exploration ); précédent : 003097; suivant : 003099A Common Pharmacophoric Footprint for AIDS Vaccine Design
Auteurs : Christoph Pisterer [Allemagne] ; Dan Mihailescu [Allemagne] ; Jeremy C. Smith [Allemagne] ; Jennifer Reed [Allemagne]Source :
- Journal of Medicinal Chemistry [ 0022-2623 ] ; 2004.
Abstract
The most promising target antigen for an HIV vaccine designed using the classic antibody strategy has been the viral coat protein gp120. Unfortunately, its high variability has prevented this approach. We examine here a 15-residue peptide derived from the CD4-binding domain of gp120. By use of molecular dynamics computer simulation, it is shown that despite considerable sequence variation, the three-dimensional structure of the peptide is preserved over the full range of clade-specific sequences. Furthermore, sequences threaded onto the structure exhibit common three-dimensional electrostatic and hydrophobic properties. These common physicochemical characteristics constitute a pharmacophoric footprint that promises to be useful in the design of a synthetic antigen for vaccine development.
Url:
DOI: 10.1021/jm031125s
Affiliations:
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Med. Chem.</title><idno type="ISSN">0022-2623</idno><idno type="eISSN">1520-4804</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published">2004</date><date type="published">2004</date><biblScope unit="vol">47</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="3723">3723</biblScope><biblScope unit="page" to="3729">3729</biblScope></imprint><idno type="ISSN">0022-2623</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2623</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The most promising target antigen for an HIV vaccine designed using the classic antibody strategy has been the viral coat protein gp120. Unfortunately, its high variability has prevented this approach. We examine here a 15-residue peptide derived from the CD4-binding domain of gp120. By use of molecular dynamics computer simulation, it is shown that despite considerable sequence variation, the three-dimensional structure of the peptide is preserved over the full range of clade-specific sequences. Furthermore, sequences threaded onto the structure exhibit common three-dimensional electrostatic and hydrophobic properties. 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